Pub. Date : 2008 Oct 1
PMID : 18619636
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | Further studies showed that 2 microM arsenite effectively inhibited PARP-1 activity. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 3 | Zinc supplementation of arsenite-treated cells restored PARP-1 activity and significantly diminished the exacerbating effect of arsenite on UVR-induced DNA strand breaks. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 4 | Combination treatments of arsenite with PARP-1 inhibitor 3-aminobenzamide or PARP-1 siRNA demonstrate that PARP-1 is the target of arsenite. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 5 | Combination treatments of arsenite with PARP-1 inhibitor 3-aminobenzamide or PARP-1 siRNA demonstrate that PARP-1 is the target of arsenite. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 6 | Combination treatments of arsenite with PARP-1 inhibitor 3-aminobenzamide or PARP-1 siRNA demonstrate that PARP-1 is the target of arsenite. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 7 | Together, these findings show that arsenite at low concentration exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity, which may represent an important mechanism underlying the co-carcinogenicity of arsenic. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |