Title : High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues.

Pub. Date : 2008 Sep

PMID : 18574460






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The IC(50) for block of resting channels at -150 mV was 2.3, 3.9 and 11.3 microM in Na(V)1.4, respectively, and 29.2 microM for 4-chloropropofol in Na(V)1.2. 4-chloropropofol immunoglobulin lambda variable 2-8 Homo sapiens
2 Estimated affinities for the fast-inactivated channel state were 81 nM, 312 nM and 227 nM for 4-iodopropofol, 4-bromopropofol and 4-chloropropofol in Na(V)1.4, and 450 nM for 4-chloropropofol in Na(V)1.2. 4-chloropropofol immunoglobulin lambda variable 2-8 Homo sapiens