Title : Neurotoxicity of cadmium on immature hippocampus and a neuroprotective role for p38 MAPK.

Pub. Date : 2008 Jul

PMID : 18541302






3 Functional Relationships(s)
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Protein Name
Organism
1 Phosphorylation of p38(MAPK) was enhanced by Cd(II) at all doses tested. cd(ii) mitogen-activated protein kinase 1 Homo sapiens
2 Inhibition of p38 MAPK by SB203580 aggravated the acute Cd(II)-induced impairment of cell viability, whereas inhibition of MEK by PD98059 did not alter the effects of Cd(II). cd(ii) mitogen-activated protein kinase 1 Homo sapiens
3 The present data suggest that in immature hippocampal cells p38 MAPK may be a part of signaling pathway that counteracts acute Cd(II) neurotoxicity. cd(ii) mitogen-activated protein kinase 1 Homo sapiens