Title : AGE/RAGE produces endothelial dysfunction in coronary arterioles in type 2 diabetic mice.

Pub. Date : 2008 Aug

PMID : 18539754






2 Functional Relationships(s)
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1 We hypothesized that impaired nitric oxide (NO)-dependent dilation (endothelial dysfunction) in type 2 diabetes results, in part, from elevated production of superoxide (O(2)(*-)) induced by the interaction of advanced glycation end products (AGE)/receptor for AGE (RAGE) and TNF-alpha signaling. Superoxides tumor necrosis factor Mus musculus
2 We hypothesized that impaired nitric oxide (NO)-dependent dilation (endothelial dysfunction) in type 2 diabetes results, in part, from elevated production of superoxide (O(2)(*-)) induced by the interaction of advanced glycation end products (AGE)/receptor for AGE (RAGE) and TNF-alpha signaling. Superoxides tumor necrosis factor Mus musculus