Title : Interfering with cellular signaling pathways enhances sensitization to combined sodium butyrate and GCV treatment in EBV-positive tumor cells.

Pub. Date : 2008 Jul

PMID : 18455826

2 Functional Relationships(s)
Compound Name
Protein Name
1 However, blocking Akt activity by expressing its dominant negative form remarkably promoted NaB and GCV-mediated cytotoxicity via a thymidine kinase (TK)-independent mechanism. nab AKT serine/threonine kinase 1 Homo sapiens
2 These results suggest that interfering with either the Akt or MEKK1 signaling pathway may be a useful therapeutic strategy to increase the sensitivity of EBV-positive tumor cells to the combination of NaB and GCV. nab AKT serine/threonine kinase 1 Homo sapiens