Title : Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells.

Pub. Date : 2008 Aug

PMID : 18448488






3 Functional Relationships(s)
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1 Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells. Nicotine signal transducer and activator of transcription 3 Homo sapiens
2 We found that nicotine simultaneously activates Stat3 and extracellular signal regulated kinase 1/2 (ERK1/2) in T24 cells. Nicotine signal transducer and activator of transcription 3 Homo sapiens
3 We conclude that through nAChR and beta-adrenoceptors, nicotine activates ERK1/2 and Stat3 signaling pathways, leading to Cyclin D1 expression and cell proliferation. Nicotine signal transducer and activator of transcription 3 Homo sapiens