Title : Distinct role of c-Jun N-terminal kinase isoforms in human neutrophil apoptosis regulated by tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor.

Pub. Date : 2008 Apr

PMID : 18439101






2 Functional Relationships(s)
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1 The JNK inhibitor markedly suppressed TNF-alpha-induced and GM-CSF-induced superoxide release. Superoxides colony stimulating factor 2 Homo sapiens
2 These findings suggest that JNK1 and JNK2 are involved in TNF-alpha-induced neutrophil apoptosis and GM-CSF-mediated antiapoptotic effect on neutrophils, respectively, and both JNK isoforms are involved in TNF-alpha-induced and GM-CSF-induced superoxide release. Superoxides colony stimulating factor 2 Homo sapiens