Title : Different mechanisms of DEHP-induced hepatocellular adenoma tumorigenesis in wild-type and Ppar alpha-null mice.

Pub. Date : 2008

PMID : 18403868






8 Functional Relationships(s)
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1 Different mechanisms of DEHP-induced hepatocellular adenoma tumorigenesis in wild-type and Ppar alpha-null mice. Diethylhexyl Phthalate peroxisome proliferator activated receptor alpha Mus musculus
2 Di (2-ethylhexyl) phthalate (DEHP) exposure is thought to lead to hepatocellular hypertrophy and hyperplasia in rodents mediated via peroxisome proliferator-activated receptor alpha (PPAR alpha). Diethylhexyl Phthalate peroxisome proliferator activated receptor alpha Mus musculus
3 Di (2-ethylhexyl) phthalate (DEHP) exposure is thought to lead to hepatocellular hypertrophy and hyperplasia in rodents mediated via peroxisome proliferator-activated receptor alpha (PPAR alpha). Diethylhexyl Phthalate peroxisome proliferator activated receptor alpha Mus musculus
4 Di (2-ethylhexyl) phthalate (DEHP) exposure is thought to lead to hepatocellular hypertrophy and hyperplasia in rodents mediated via peroxisome proliferator-activated receptor alpha (PPAR alpha). Diethylhexyl Phthalate peroxisome proliferator activated receptor alpha Mus musculus
5 Di (2-ethylhexyl) phthalate (DEHP) exposure is thought to lead to hepatocellular hypertrophy and hyperplasia in rodents mediated via peroxisome proliferator-activated receptor alpha (PPAR alpha). Diethylhexyl Phthalate peroxisome proliferator activated receptor alpha Mus musculus
6 A recent study revealed that long-term exposure to relatively low-dose DEHP (0.05%) caused liver tumors including hepatocellular carcinomas, hepatocellular adenomas, and chologiocellular carcinomas at a higher incidence in Ppar alpha-null mice (25.8%) than in wild-type mice (10.0%). Diethylhexyl Phthalate peroxisome proliferator activated receptor alpha Mus musculus
7 The gene expressions of apoptotic peptidase activating factor 1 (Apaf1) and DNA-damage-inducible 45 alpha (Gadd45a) were increased in the hepatocellular adenoma tissues of wild-type mice exposed to DEHP, whereas they were unchanged in corresponding tissues of Ppar alpha-null mice. Diethylhexyl Phthalate peroxisome proliferator activated receptor alpha Mus musculus
8 Taken together, DEHP may induce hepatocellular adenomas, in part, via suppression of G2/M arrest regulated by Gadd45a and caspase 3-dependent apoptosis in Ppar alpha-null mice, but these genes may not be involved in tumorigenesis in the wild-type mice. Diethylhexyl Phthalate peroxisome proliferator activated receptor alpha Mus musculus