Title : Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder.

Pub. Date : 2008 Jun

PMID : 18320559






2 Functional Relationships(s)
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1 OBJECTIVE: To test association of dopamine receptor D3 (DRD-3) gene polymorphisms with olanzapine response in genetic samples from a registration phase clinical trial. Olanzapine dopamine receptor D3 Homo sapiens
2 CONCLUSIONS: Gly/gly DRD-3 genotype predicted statistically and clinically significantly better acute positive symptom reduction compared with other ser-9-gly genotypes in patients treated with olanzapine. Olanzapine dopamine receptor D3 Homo sapiens