Title : Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension.

Pub. Date : 2008 Mar

PMID : 18316027






1 Functional Relationships(s)
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1 Transgenic mice expressing dominant-negative mutations in PPARgamma under the control of a smooth-muscle-specific promoter exhibit a loss of responsiveness to nitric oxide and striking alterations in contractility in the aorta, hypertrophy and inward remodeling in the cerebral microcirculation, and systolic hypertension. Nitric Oxide peroxisome proliferator activated receptor gamma Mus musculus