Title : Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir.

Pub. Date : 2008 Feb 26

PMID : 18302767






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 On the other hand, only Nelfinavir increased significantly Notch 4 processing, Notch4 intracellular domain nuclear localization and the expression of notch intracellular domain targets NFkappaB and matrix metalloproteinase 2. Nelfinavir nuclear factor kappa B subunit 1 Homo sapiens
2 CONCLUSION: Nelfinavir affects Notch 4 processing that results in induction of expression of the pro-angiogenic genes NFkappaB and matrix metalloproteinase 2 in cerebral endothelial cells. Nelfinavir nuclear factor kappa B subunit 1 Homo sapiens