Title : Myristoylated alanine-rich C kinase substrate, but not Ca2+/calmodulin-dependent protein kinase II, is the mediator in cortical granules exocytosis.

Pub. Date : 2008 May

PMID : 18296509






3 Functional Relationships(s)
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1 Microinjecting eggs with mutant-unphosphorylatable MARCKS reduced the intensity of 12-O-tetradecanoylphorbol 13-acetate or ionomycin-induced CGE by 50%, indicating that phosphorylation of MARCKS by novel and/or conventional PKCs (n/cPKCs) is a pivotal event associated with CGE. Ionomycin myristoylated alanine rich protein kinase C substrate Homo sapiens
2 Microinjecting eggs with mutant-unphosphorylatable MARCKS reduced the intensity of 12-O-tetradecanoylphorbol 13-acetate or ionomycin-induced CGE by 50%, indicating that phosphorylation of MARCKS by novel and/or conventional PKCs (n/cPKCs) is a pivotal event associated with CGE. Ionomycin myristoylated alanine rich protein kinase C substrate Homo sapiens
3 Moreover, we were able to demonstrate cPKCs involvement in ionomycin-induced MARCKS translocation and CGE. Ionomycin myristoylated alanine rich protein kinase C substrate Homo sapiens