Title : Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells.

Pub. Date : 2008 Jun

PMID : 18218611






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 BT-GMZ bound to purified yeast HSP82 (homologue to mammalian HSP90AB1) and EEF1A1, but not to TEF3 or HBS1, and was competed by unlabeled gamendazole. bt-gmz Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C