Title : High-glucose-induced prostaglandin E(2) and peroxisome proliferator-activated receptor delta promote mouse embryonic stem cell proliferation.

Pub. Date : 2008 Mar

PMID : 18096720






5 Functional Relationships(s)
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1 Subsequently, high glucose-induced PGE(2) stimulated PPARdelta expression directly or through Akt phosphorylation indirectly through the E type prostaglandin receptor receptors. Glucose peroxisome proliferator activator receptor delta Mus musculus
2 The PPARdelta antagonist inhibited the 25 mM glucose-induced DNA synthesis. Glucose peroxisome proliferator activator receptor delta Mus musculus
3 Moreover, transfection with a pool of PPARdelta-specific small interfering RNA inhibited the 25 mM glucose-induced DNA synthesis and G1/S phase progression. Glucose peroxisome proliferator activator receptor delta Mus musculus
4 Twenty-five millimolar glucose also increased the level of the cell cycle regulatory proteins (cyclin E/cyclin-dependent kinase [CDK] 2 and cyclin D1/CDK 4) and decreased p21(WAF1/Cip1) and p27(Kip1), which were blocked by the inhibition of the cPLA(2), COX-2, or PPARdelta pathways. Glucose peroxisome proliferator activator receptor delta Mus musculus
5 In conclusion, high glucose promotes mouse ESC growth in part through the cPLA(2)-mediated PGE(2) synthesis and in part through PPARdelta pathways. Glucose peroxisome proliferator activator receptor delta Mus musculus