Pub. Date : 2008 Mar
PMID : 18096720
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Subsequently, high glucose-induced PGE(2) stimulated PPARdelta expression directly or through Akt phosphorylation indirectly through the E type prostaglandin receptor receptors. | Glucose | peroxisome proliferator activator receptor delta | Mus musculus |
| 2 | The PPARdelta antagonist inhibited the 25 mM glucose-induced DNA synthesis. | Glucose | peroxisome proliferator activator receptor delta | Mus musculus |
| 3 | Moreover, transfection with a pool of PPARdelta-specific small interfering RNA inhibited the 25 mM glucose-induced DNA synthesis and G1/S phase progression. | Glucose | peroxisome proliferator activator receptor delta | Mus musculus |
| 4 | Twenty-five millimolar glucose also increased the level of the cell cycle regulatory proteins (cyclin E/cyclin-dependent kinase [CDK] 2 and cyclin D1/CDK 4) and decreased p21(WAF1/Cip1) and p27(Kip1), which were blocked by the inhibition of the cPLA(2), COX-2, or PPARdelta pathways. | Glucose | peroxisome proliferator activator receptor delta | Mus musculus |
| 5 | In conclusion, high glucose promotes mouse ESC growth in part through the cPLA(2)-mediated PGE(2) synthesis and in part through PPARdelta pathways. | Glucose | peroxisome proliferator activator receptor delta | Mus musculus |