Pub. Date : 2007 Nov
PMID : 18025279
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glycosaminoglycans and their synthetic mimetics inhibit RANTES-induced migration and invasion of human hepatoma cells. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |
| 2 | The CC-chemokine regulated on activation, normal T-cell expressed, and presumably secreted (RANTES)/CCL5 mediates its biological activities through activation of G protein-coupled receptors, CCR1, CCR3, or CCR5, and binds to glycosaminoglycans. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |
| 3 | The CC-chemokine regulated on activation, normal T-cell expressed, and presumably secreted (RANTES)/CCL5 mediates its biological activities through activation of G protein-coupled receptors, CCR1, CCR3, or CCR5, and binds to glycosaminoglycans. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |
| 4 | RANTES/CCL5 binding to these cells depends on CCR1 and glycosaminoglycans. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |
| 5 | RANTES/CCL5 binding to these cells depends on CCR1 and glycosaminoglycans. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |
| 6 | The fact that RANTES/CCL5-induced migration and invasion of Huh7 cells are both strongly inhibited by anti-CCR1 antibodies and heparin, as well as by beta-d-xyloside treatment of the cells, suggests that CCR1 and glycosaminoglycans are involved in these events. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |
| 7 | The fact that RANTES/CCL5-induced migration and invasion of Huh7 cells are both strongly inhibited by anti-CCR1 antibodies and heparin, as well as by beta-d-xyloside treatment of the cells, suggests that CCR1 and glycosaminoglycans are involved in these events. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |
| 8 | We then show by surface plasmon resonance that synthetic glycosaminoglycan mimetics, OTR4120 or OTR4131, directly bind to RANTES/CCL5. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |
| 9 | We then show by surface plasmon resonance that synthetic glycosaminoglycan mimetics, OTR4120 or OTR4131, directly bind to RANTES/CCL5. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |
| 10 | Therefore, targeting the RANTES-glycosaminoglycan interaction could be a new therapeutic approach for human hepatocellular carcinoma. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |