Title : GSK3 promotes arsenite-induced apoptosis via facilitation of mitochondria disruption.

Pub. Date : 2008 May

PMID : 17849503






1 Functional Relationships(s)
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1 Moreover, arsenite induced the translocation of Bax and p53 to the mitochondria and the activation-associated oligomerization of Bax, and these crucial events were reduced by inhibition of GSK3, indicating that GSK3 promotes arsenite-induced apoptosis by facilitating signals leading to mitochondrial apoptotic events. arsenite tumor protein p53 Homo sapiens