Title : Can the protective actions of JAK-STAT in the heart be exploited therapeutically? Parsing the regulation of interleukin-6-type cytokine signaling.

Pub. Date : 2007 Aug

PMID : 17703129






1 Functional Relationships(s)
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1 Moreover, we hypothesize that hyperactivation of the JAK kinases, particularly JAK2, mismatched STAT3 serine-tyrosine phosphorylation or heightened STAT3 transcriptional activity, and SOCS3 induction may ultimately prove detrimental. Tyrosine Janus kinase 1 Homo sapiens