Title : Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis.

Pub. Date : 2008 Feb 14

PMID : 17700521






3 Functional Relationships(s)
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1 Keratinocytes from K5.Stat3C mice showed increased survival following exposure to 7,12-dimethylbenz[a]anthracene (DMBA) and enhanced proliferation following exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate signal transducer and activator of transcription 3 Mus musculus
2 Keratinocytes from K5.Stat3C mice showed increased survival following exposure to 7,12-dimethylbenz[a]anthracene (DMBA) and enhanced proliferation following exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate signal transducer and activator of transcription 3 Mus musculus
3 In two-stage chemical carcinogenesis experiments using DMBA as the tumor initiator and TPA as the promoter, K5.Stat3C mice developed skin tumors with a shorter latency and in much greater number compared to non-transgenic littermates. Tetradecanoylphorbol Acetate signal transducer and activator of transcription 3 Mus musculus