Title : Liver derived endogenous opioids may interfere with the therapeutic effect of interferon in chronic hepatitis C.

Pub. Date : 2008

PMID : 17692472






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Met-enkephalin, one of the endogenous opioid peptides, can bind to the same receptors to which morphine binds, triggering similar receptor-mediated effects. Morphine proopiomelanocortin Homo sapiens
2 Analogous to the effect of morphine on the hepatitis C-replicon containing liver cells, we hypothesize that Met-enkephalin enhances the replication of the hepatitis C virus in liver cells, and that it interferes with the antiviral effect of interferon, contributing to the lack of efficacy of this medication in the treatment of this viral infection in some patients. Morphine proopiomelanocortin Homo sapiens