Title : Cleft-type cyclophanes confer neuroprotection against excitatory neurotoxicity in vitro and in vivo through inhibition of NMDA receptors.

Pub. Date : 2007 Sep

PMID : 17681353






1 Functional Relationships(s)
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1 The cleft-type cyclophanes (ACCn, DNCn and TsDCn) were found to strongly inhibit macroscopic currents at heteromeric NMDA receptors (NR1/NR2) but not AMPA receptors expressed in Xenopus oocytes at voltage-clamp recording. cyclophanes glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis