Title : Essential role of extracellular SOD in reparative neovascularization induced by hindlimb ischemia.

Pub. Date : 2007 Aug 17

PMID : 17601801






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The extracellular superoxide dismutase (ecSOD) is one of the major antioxidant enzymes against O2- in blood vessels; however, its role in neovascularization induced by tissue ischemia is unknown. Superoxides superoxide dismutase 3, extracellular Mus musculus
2 The extracellular superoxide dismutase (ecSOD) is one of the major antioxidant enzymes against O2- in blood vessels; however, its role in neovascularization induced by tissue ischemia is unknown. Superoxides superoxide dismutase 3, extracellular Mus musculus
3 Impaired neovascularization in ecSOD(-/-) mice is associated with enhanced O2- production, TUNEL-positive apoptotic cells and decreased levels of NO2-/NO3- and cGMP in ischemic tissues as compared with wild-type mice, and it is rescued by infusion of the SOD mimetic tempol. Superoxides superoxide dismutase 3, extracellular Mus musculus
4 Thus, ecSOD in BM and ischemic tissues induced by hindlimb ischemia may represent an important compensatory mechanism that blunts the overproduction of O2-, which may contribute to reparative neovascularization in response to ischemic injury. Superoxides superoxide dismutase 3, extracellular Mus musculus