Title : Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.

Pub. Date : 2007 Jul 26

PMID : 17585855






1 Functional Relationships(s)
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1 The inhibition mechanism was investigated through NMR studies of the reaction between 11d and benzylmercaptan as a model for Cys-285 in the active site of caspase-3. Cysteine caspase 3 Homo sapiens