Title : Role of the small GTPase Rac in p22phox-dependent NADPH oxidases.

Pub. Date : 2007 Sep

PMID : 17583407






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The superoxide-producing phagocyte NADPH oxidase gp91(phox)/Nox2 and the non-phagocytic oxidases Nox1 and Nox3 each form a complex in the membrane with p22(phox), which provides both stabilization and a docking site for organizer proteins. Superoxides pleckstrin Homo sapiens
2 The superoxide-producing phagocyte NADPH oxidase gp91(phox)/Nox2 and the non-phagocytic oxidases Nox1 and Nox3 each form a complex in the membrane with p22(phox), which provides both stabilization and a docking site for organizer proteins. Superoxides pleckstrin Homo sapiens
3 Although Nox3 complexed with p22(phox) constitutively produce superoxide, the production can be enhanced by supportive proteins. Superoxides pleckstrin Homo sapiens
4 When these oxidases use Noxo1 as an organizer instead of p47(phox), they produce a small but significant amount of superoxide without expression of Rac1(Q61L), although the production is enhanced by Rac1(Q61L). Superoxides pleckstrin Homo sapiens
5 When these oxidases use Noxo1 as an organizer instead of p47(phox), they produce a small but significant amount of superoxide without expression of Rac1(Q61L), although the production is enhanced by Rac1(Q61L). Superoxides pleckstrin Homo sapiens
6 We also demonstrate that, in the Nox3-based oxidase containing solely p67(phox) as supportive protein, expression of Rac1(Q61L) enhances not only superoxide production but also membrane translocation of p67(phox). Superoxides pleckstrin Homo sapiens