Title : Vasopressin and angiotensin receptors of the medial septal area of the brain in the control of thirst and salt appetite induced by vasopressin in water-deprived and sodium-depleted rats.

Pub. Date : 2007 Oct

PMID : 17573101






5 Functional Relationships(s)
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1 Vasopressin and angiotensin receptors of the medial septal area of the brain in the control of thirst and salt appetite induced by vasopressin in water-deprived and sodium-depleted rats. Sodium arginine vasopressin Rattus norvegicus
2 A stainless steel cannula was implanted into the medial septal area (MSA) of male Holtzman rats AVP injection enhanced water and sodium intake in a dose-dependent manner. Sodium arginine vasopressin Rattus norvegicus
3 Pretreatment with V(1) antagonist injected into the MSA produced a dose-dependent reduction, whereas prior injection of V(2) antagonist increased, in a dose-dependent manner, the water and sodium responses elicited by the administration of AVP. Sodium arginine vasopressin Rattus norvegicus
4 Both AT(1) and AT(2) antagonists administered into the MSA elicited a concentration-dependent decrease in water and sodium intake induced by AVP, while simultaneous injection of the two antagonists was more effective in decreasing AVP responses. Sodium arginine vasopressin Rattus norvegicus
5 These results also indicate that the increase in water and sodium intake induced by AVP was mediated primarily by MSA AT(1) receptors. Sodium arginine vasopressin Rattus norvegicus