Title : TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death.

Pub. Date : 2007 Jun 8

PMID : 17560373






2 Functional Relationships(s)
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1 TNF signaling enables the generation of superoxide in phagocytic and vascular cells through the activation of the NADPH oxidase Nox2/gp91. Superoxides tumor necrosis factor Mus musculus
2 Moreover, the prevention of TNF-induced superoxide generation with dominant-negative mutants of TRADD or Rac1, as well as knockdown of Nox1 using siRNA, inhibits necrosis. Superoxides tumor necrosis factor Mus musculus