Title : Identification of human cytochrome P450 enzymes involved in the major metabolic pathway of fluvoxamine.

Pub. Date : 2007 Feb

PMID : 17484519






2 Functional Relationships(s)
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1 Identification of human cytochrome P450 enzymes involved in the major metabolic pathway of fluvoxamine. Fluvoxamine cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 The formation of fluvoxamino alcohol from fluvoxamine in pooled human liver microsomes was significantly inhibited by quinidine, a relatively specific CYP2D6 inhibitor, with a Ki value of 2.2 microM, whereas other several relatively specific CYP inhibitors did not inhibit the formation of fluvoxamino alcohol. Fluvoxamine cytochrome P450 family 4 subfamily F member 3 Homo sapiens