Title : Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir.

Pub. Date : 2007 May 1

PMID : 17483362






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir. Nelfinavir phosphatase and tensin homolog Homo sapiens
2 Nelfinavir decreased Akt phosphorylation and enhanced radiosensitization in U251MG and U87MG glioblastoma cells, both of which are PTEN deficient. Nelfinavir phosphatase and tensin homolog Homo sapiens
3 In the derivative line U251MG-PTEN, induction of wild-type PTEN with doxycycline decreased P-Akt expression and increased radiosensitivity to a similar extent as nelfinavir. Nelfinavir phosphatase and tensin homolog Homo sapiens