Title : Use of RNA interference to elucidate the effect of MYCN on cell cycle in neuroblastoma.

Pub. Date : 2008 Feb

PMID : 17420990






1 Functional Relationships(s)
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1 In evaluating the mechanisms by which retinoic acid (RA) or nerve growth factor (NGF) decrease cell number in MYCN amplified NB cells, we have identified a number of proteins whose expression either decreases (E2F, CDC2, CDK6, cyclin dependent kinase activity) or increases (p27) in association with a decrease in MYCN expression. Tretinoin cyclin dependent kinase 1 Homo sapiens