Title : Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA.

Pub. Date : 2007 Jun 15

PMID : 17420132






1 Functional Relationships(s)
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1 In particular, our data suggest that a narrower active site cleft, together with a different hydrogen bond network arrangement of hCA VA compared to hCA II, may account for the different Kd values of zonisamide and topiramate toward these physiologically relevant hCA isoforms. Hydrogen carbonic anhydrase 5A Homo sapiens