Title : Deficient peroxide detoxification underlies the susceptibility of oligodendrocyte progenitors to dopamine toxicity.

Pub. Date : 2007 May

PMID : 17400258






2 Functional Relationships(s)
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1 In addition, the glutathione (GSH) analog (GME), blocks DA-induced superoxide accumulation, heme-oxygenase-1 (HO-1) expression and caspase-3 activation, and reduces cell death, while the glutathione synthetase inhibitor, buthionine sulfoximine, potentiates DA-induced HO-1 expression and cell death. Glutathione caspase 3 Homo sapiens
2 In addition, the glutathione (GSH) analog (GME), blocks DA-induced superoxide accumulation, heme-oxygenase-1 (HO-1) expression and caspase-3 activation, and reduces cell death, while the glutathione synthetase inhibitor, buthionine sulfoximine, potentiates DA-induced HO-1 expression and cell death. Glutathione caspase 3 Homo sapiens