Title : GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

Pub. Date : 2007 Mar 21

PMID : 17332749






1 Functional Relationships(s)
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1 In a neuronal cell system, mutations of glycine residues G29 and G33 of the GxxxG motif gradually attenuate the TMS dimerization strength, specifically reduce the formation of Abeta42, leave the level of Abeta40 unaffected, but increase Abeta38 and shorter Abeta species. Glycine amyloid beta precursor protein Homo sapiens