Title : Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin.

Pub. Date : 2007 Mar

PMID : 17332528






4 Functional Relationships(s)
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1 Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin. Glucose proopiomelanocortin Homo sapiens
2 The N-43/5 POMC neurons may therefore be an appropriate cell model to study glucose-sensing mechanisms in the hypothalamus. Glucose proopiomelanocortin Homo sapiens
3 In N-43/5 POMC neurons, increasing glucose concentrations decreased phospho-AMPK activity. Glucose proopiomelanocortin Homo sapiens
4 As a relevant downstream effect, we found that POMC transcription increased with 2.8 and 16.7 mM glucose. Glucose proopiomelanocortin Homo sapiens