Title : Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice.

Pub. Date : 2007 Jun

PMID : 17327360






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Hcy is mistakenly selected in place of methionine by methionyl-tRNA synthetase during protein biosynthesis, which results in the formation of Hcy-thiolactone and initiates a pathophysiological pathway that has been implicated in human vascular disease. Homocysteine methionyl-tRNA synthetase 1 Homo sapiens