Title : Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2.

Pub. Date : 2007 Mar

PMID : 17290288






2 Functional Relationships(s)
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1 Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2. Tyrosine Janus kinase 1 Homo sapiens
2 Moreover, we provide strong evidence that both the induction of eIF2alpha phosphorylation and inhibition of protein synthesis by IFN are impaired in cells lacking Jak1 or Tyk2, which corresponds to a lack of induction of PKR tyrosine phosphorylation. Tyrosine Janus kinase 1 Homo sapiens