Title : Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines.

Pub. Date : 2007 Mar

PMID : 17273769






6 Functional Relationships(s)
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1 Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines. Fenretinide DNA damage inducible transcript 3 Homo sapiens
2 Oxidative stress induced by fenretinide has been shown to mediate apoptosis through a mitochondrial pathway by the induction of a transcription factor CCAAT/enhancer binding protein homologous protein (CHOP) and Bak. Fenretinide DNA damage inducible transcript 3 Homo sapiens
3 Oxidative stress induced by fenretinide has been shown to mediate apoptosis through a mitochondrial pathway by the induction of a transcription factor CCAAT/enhancer binding protein homologous protein (CHOP) and Bak. Fenretinide DNA damage inducible transcript 3 Homo sapiens
4 In this study, we report that fenretinide induces death receptor 5 (DR5)/TRAIL-R2 up-regulation via the induction of the transcription factor CHOP in colon cancer cell lines. Fenretinide DNA damage inducible transcript 3 Homo sapiens
5 Furthermore, fenretinide increased DR5 promoter activity and the enhanced activity decreased by mutation of the CHOP binding site. Fenretinide DNA damage inducible transcript 3 Homo sapiens
6 CHOP was also up-regulated by fenretinide at the promoter level. Fenretinide DNA damage inducible transcript 3 Homo sapiens