Title : Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours.

Pub. Date : 2007 Mar

PMID : 17216584






5 Functional Relationships(s)
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1 Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours. Fenretinide phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens
2 Noxa expression was induced by fenretinide in neuroblastoma and melanoma cells, including those with mutated p53, and this induction was abolished by antioxidants. Fenretinide phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens
3 Knockdown of p53 by RNA interference (RNAi) demonstrated upregulation of Noxa protein levels in response to fenretinide was p53-independent, although evidence suggested that Noxa may be transcriptionally regulated by p53. Fenretinide phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens
4 RNAi-mediated down-regulation of Noxa inhibited apoptosis in response to fenretinide or thapsigargin, whereas apoptosis induced by cisplatin or temozolomide was unaffected. Fenretinide phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens
5 These data demonstrate the importance of Noxa induction in determining the apoptotic response to fenretinide and emphasise the role of Noxa in p53-independent apoptosis. Fenretinide phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens