Title : Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism.

Pub. Date : 2006 Nov

PMID : 17010161






4 Functional Relationships(s)
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1 Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism. glyceryl 2-arachidonate 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus
2 The main objective of this study was to determine whether activation of the 5-HT(2A) receptor leads to the production and release of the endocannabinoid 2-arachidonoylglycerol. glyceryl 2-arachidonate 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus
3 Our results indicate that 5-HT(2A) receptor activation stimulates the formation and release of 2-arachidonoylglycerol. glyceryl 2-arachidonate 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus
4 The 5-HT(2A) receptor-dependent release of 2-arachidonoylglycerol was partially dependent on phosphatidylinositol-specific phospholipase C activation. glyceryl 2-arachidonate 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus