Title : The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading.

Pub. Date : 2006 Nov 17

PMID : 16980295






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 ATP binding to RFC powers recruitment and opening of PCNA and activates a gamma-phosphate sensor in ATP site C that promotes DNA association. gamma-phosphate proliferating cell nuclear antigen Homo sapiens
2 PCNA closure severs contact to RFC subunits D and E (RFC2 and RFC5), and the gamma-phosphate sensor of ATP site C is switched off, resulting in low affinity of RFC for DNA and ejection of RFC from the site of PCNA loading. gamma-phosphate proliferating cell nuclear antigen Homo sapiens