Title : Inhibition of IL-8 release from CFTR-deficient lung epithelial cells following pre-treatment with fenretinide.

Pub. Date : 2006 Nov

PMID : 16979119






5 Functional Relationships(s)
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1 Inhibition of IL-8 release from CFTR-deficient lung epithelial cells following pre-treatment with fenretinide. Fenretinide C-X-C motif chemokine ligand 8 Homo sapiens
2 Clinically relevant concentrations of fenretinide (1.25, 2.5 and 5 microM) inhibited TNF-alpha-induced IL-8 production of CF cells by up to 73% but had no effect or increased the IL-8 production in non-CF cells. Fenretinide C-X-C motif chemokine ligand 8 Homo sapiens
3 Although fenretinide treatment was associated with a higher intracellular ceramide content in the mutant DeltaF508 CFTR cells, the fenretinide-mediated decrease in IL-8 secretion was not consistently explained by changes in the intracellular content of this sphingolipid. Fenretinide C-X-C motif chemokine ligand 8 Homo sapiens
4 The fenretinide mediated decrease in IL-8 release in CF cells under TNF-alpha stimulated conditions presents the possibility that the lung inflammation in CF could be attenuated via low dose fenretinide treatment. Fenretinide C-X-C motif chemokine ligand 8 Homo sapiens
5 The fenretinide mediated decrease in IL-8 release in CF cells under TNF-alpha stimulated conditions presents the possibility that the lung inflammation in CF could be attenuated via low dose fenretinide treatment. Fenretinide C-X-C motif chemokine ligand 8 Homo sapiens