Title : Multifactorial control of insulin receptor gene expression in human cell lines.

Pub. Date : 1990 Aug 16

PMID : 1697168






2 Functional Relationships(s)
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1 We found that (i) forskolin reduces insulin receptor mRNA levels; (ii) the effects of either forskolin or dexamethasone on insulin receptor mRNA levels are near completely abolished in glucose-starved cells; (iii) 2-mercaptoethanol and heat shock, besides previously described stress conditions (glycosylatyon inhibitors), reduce insulin receptor mRNA levels. Dexamethasone insulin receptor Homo sapiens
2 We found that (i) forskolin reduces insulin receptor mRNA levels; (ii) the effects of either forskolin or dexamethasone on insulin receptor mRNA levels are near completely abolished in glucose-starved cells; (iii) 2-mercaptoethanol and heat shock, besides previously described stress conditions (glycosylatyon inhibitors), reduce insulin receptor mRNA levels. Dexamethasone insulin receptor Homo sapiens