Title : High glucose activates pituitary proopiomelanocortin gene expression: possible role of free radical-sensitive transcription factors.

Pub. Date : 2007 May

PMID : 16921546






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1 High glucose activates pituitary proopiomelanocortin gene expression: possible role of free radical-sensitive transcription factors. Glucose proopiomelanocortin Homo sapiens
2 RESULTS: We found that high glucose concentration (24 mM) significantly stimulated the 5"-promoter activity of POMC gene. Glucose proopiomelanocortin Homo sapiens
3 Furthermore, the stimulatory effect of high glucose on POMC gene was eliminated by NF-kappaB and AP1 inhibitors, suggesting the involvement of the transcriptional factors. Glucose proopiomelanocortin Homo sapiens
4 CONCLUSIONS: Our data suggest that hyperglycemia activates POMC gene expression, at least partly, via NF-kappaB/AP1, and that high-glucose-induced free radical generation may mediate the activation of these transcription factors, which in turn stimulates the transcription of POMC gene. Glucose proopiomelanocortin Homo sapiens
5 CONCLUSIONS: Our data suggest that hyperglycemia activates POMC gene expression, at least partly, via NF-kappaB/AP1, and that high-glucose-induced free radical generation may mediate the activation of these transcription factors, which in turn stimulates the transcription of POMC gene. Glucose proopiomelanocortin Homo sapiens