Title : Exploring the S4 and S1 prime subsite specificities in caspase-3 with aza-peptide epoxide inhibitors.

Pub. Date : 2006 Aug 1

PMID : 16866351






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Unlike the clan CA cysteine proteases, the catalytic histidine in caspase-3 plays a critical role during protonation and subsequent ring opening of the epoxide moiety and facilitates the nucleophilic attack by the active site cysteine. Cysteine caspase 3 Homo sapiens