Pub. Date : 2006 Sep 1
PMID : 16807236
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CCL5 binding to glycosaminoglycans (GAGs) on the cell surface or in extracellular matrix sequesters CCL5, thereby immobilizing CCL5 to provide the directional signal. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |
| 2 | CCL5 binding to glycosaminoglycans (GAGs) on the cell surface or in extracellular matrix sequesters CCL5, thereby immobilizing CCL5 to provide the directional signal. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |
| 3 | CCL5 binding to glycosaminoglycans (GAGs) on the cell surface or in extracellular matrix sequesters CCL5, thereby immobilizing CCL5 to provide the directional signal. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |
| 4 | We show that CCL5-CCR5-mediated apoptosis is dependent on cell surface GAG binding. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |
| 5 | Moreover, the non-GAG binding variant, (44AANA47)-CCL5, fails to induce apoptosis. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |
| 6 | Viewed altogether, these data suggest that CCL5-GAG binding and CCL5 aggregation are important for CCL5 activity in T cells, specifically in the context of CCR5-mediated apoptosis. | Glycosaminoglycans | C-C motif chemokine ligand 5 | Homo sapiens |