Title : Effects of treatment with acamprosate on beta-endorphin plasma concentration in humans with high alcohol preference.

Pub. Date : 2006 Aug 14

PMID : 16782270






3 Functional Relationships(s)
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1 Effects of treatment with acamprosate on beta-endorphin plasma concentration in humans with high alcohol preference. Alcohols proopiomelanocortin Homo sapiens
2 Treatment with acamprosate, a compound used for relapse prevention treatment of alcoholism, was recently shown to be associated with increased plasma concentration of beta-endorphin in rats selectively bred for high alcohol preference. Alcohols proopiomelanocortin Homo sapiens
3 Since beta-endorphin deficiency was earlier associated with alcohol craving and anxiety during withdrawal, abstinence maintaining effects of acamprosate might at least be partially related with the ability to modulate opioidergic activity especially in the subsample of HP patients with an attenuated opioidergic activity during this state. Alcohols proopiomelanocortin Homo sapiens