Title : The persistent DDT metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, alters thyroid hormone-dependent genes, hepatic cytochrome P4503A, and pregnane X receptor gene expressions in Atlantic salmon (Salmo salar) Parr.

Pub. Date : 2006 Jun

PMID : 16764480






4 Functional Relationships(s)
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1 The persistent DDT metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, alters thyroid hormone-dependent genes, hepatic cytochrome P4503A, and pregnane X receptor gene expressions in Atlantic salmon (Salmo salar) Parr. Dichlorodiphenyl Dichloroethylene cytochrome P450 3A27 Salmo salar
2 Exposure to T4 and DDE, both singly and in combination, resulted in a parallel pattern of CYP3A and PXR mRNA induction in the liver. Dichlorodiphenyl Dichloroethylene cytochrome P450 3A27 Salmo salar
3 The hepatic modulation of CYP3A and PXR transcript levels by DDE represents a novel aspect of DDE toxicity that, to our knowledge, has not been demonstrated previously in fish. Dichlorodiphenyl Dichloroethylene cytochrome P450 3A27 Salmo salar
4 The hepatic modulation of CYP3A and PXR transcript levels by DDE represents a novel aspect of DDE toxicity that, to our knowledge, has not been demonstrated previously in fish. Dichlorodiphenyl Dichloroethylene cytochrome P450 3A27 Salmo salar