Title : Effect of platelet-activating factor on tumor necrosis factor-induced superoxide generation from human neutrophils. Possible involvement of G proteins.

Pub. Date : 1991 Dec

PMID : 1668107






3 Functional Relationships(s)
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1 Effect of platelet-activating factor on tumor necrosis factor-induced superoxide generation from human neutrophils. Superoxides PCNA clamp associated factor Homo sapiens
2 PAF alone (0.1 pM to 0.1 nM) failed to evoke superoxide production; however, when PAF was added for 10 min to cells upon prior incubation with 10 ng/mL TNF for 50 min, superoxide production was significantly enhanced as compared to that induced by TNF alone. Superoxides PCNA clamp associated factor Homo sapiens
3 Pretreatment of the PMN with either pertussis or cholera toxin attenuated the PAF amplified superoxide production in TNF stimulated cells, suggesting that G proteins sensitive to these toxins may be involved in the mechanisms controlling amplification. Superoxides PCNA clamp associated factor Homo sapiens