Title : Involvement of platelet-activating factor in endotoxin-induced priming of rabbit polymorphonuclear leukocytes.

Pub. Date : 1991 Mar-Apr

PMID : 1665713






3 Functional Relationships(s)
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1 There was a close relationship between the concentration-response curve for increases in PAF synthesis and that for enhanced O2- generation. Superoxides PCNA clamp associated factor Homo sapiens
2 The possibility that PAF was causally linked to enhanced O2- generation in primed PMNs was investigated using compounds previously reported to reduce PAF generation, namely the serine protease inhibitor, tosyl-phenylalanine chloromethylketone, and the phospholipase A2 inhibitor, bromophenacylbromide. Superoxides PCNA clamp associated factor Homo sapiens
3 We examined the possibility that PAF acted in an autocrine fashion to enhance O2- generation following its release from fMLP-stimulated PMNs. Superoxides PCNA clamp associated factor Homo sapiens