Title : L-type calcium channel ligands block nicotine-induced signaling to CREB by inhibiting nicotinic receptors.

Pub. Date : 2006 Jul

PMID : 16631827






4 Functional Relationships(s)
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1 L-type calcium channel ligands block nicotine-induced signaling to CREB by inhibiting nicotinic receptors. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus
2 We found that 10microM nicotine and 40mM K(+) both reversibly depolarize SCG neurons to -20mV, sufficient to activate LTCCs and downstream signaling, including induction of nuclear phospho-CREB (pCREB); this induction was blocked by LTCC antagonists. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus
3 Interestingly, the effects of LTCC antagonists on nicotine-induced signaling to CREB are not mediated by their actions on LTCCs, but rather via inhibition of nAChRs, which prevents nicotine-induced depolarization. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus
4 Interestingly, the effects of LTCC antagonists on nicotine-induced signaling to CREB are not mediated by their actions on LTCCs, but rather via inhibition of nAChRs, which prevents nicotine-induced depolarization. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus