Pub. Date : 2006 Aug
PMID : 16624894
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | N-Acetylgalactosamine 4,6-O-sulfate residues mediate binding and activation of heparin cofactor II by porcine mucosal dermatan sulfate. | Dermatan Sulfate | serpin family D member 1 | Homo sapiens |
| 2 | Dermatan sulfate (DS) accelerates the inhibition of thrombin by heparin cofactor II (HCII). | Dermatan Sulfate | serpin family D member 1 | Homo sapiens |
| 3 | Dermatan sulfate (DS) accelerates the inhibition of thrombin by heparin cofactor II (HCII). | Dermatan Sulfate | serpin family D member 1 | Homo sapiens |
| 4 | Dermatan sulfate (DS) accelerates the inhibition of thrombin by heparin cofactor II (HCII). | Dermatan Sulfate | serpin family D member 1 | Homo sapiens |
| 5 | Dermatan sulfate (DS) accelerates the inhibition of thrombin by heparin cofactor II (HCII). | Dermatan Sulfate | serpin family D member 1 | Homo sapiens |
| 6 | DS from porcine intestinal mucosa has a much lower content of this disaccharide but activates HCII with potency similar to that of porcine skin DS. | Dermatan Sulfate | serpin family D member 1 | Homo sapiens |
| 7 | Therefore, we sought to characterize oligosaccharides from porcine mucosal DS that interact with HCII. | Dermatan Sulfate | serpin family D member 1 | Homo sapiens |
| 8 | These data support the hypothesis that modification of IdoA-->GalNAc4SO3 subunits in the DS polymer by either 2-O-sulfation of IdoA or 6-O-sulfation of GalNAc can generate molecules with HCII-binding sites and anticoagulant activity. | Dermatan Sulfate | serpin family D member 1 | Homo sapiens |