Title : Aging-dependent alterations in synaptic plasticity and memory in mice that overexpress extracellular superoxide dismutase.

Pub. Date : 2006 Apr 12

PMID : 16611809






2 Functional Relationships(s)
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1 At the molecular level, aged EC-SOD transgenic mice had lower superoxide levels, a decrease in protein carbonyl levels, and a decrease in p38 and extracellular signal-regulated kinase 2 phosphorylation compared with aged wild-type mice. Superoxides superoxide dismutase 3, extracellular Mus musculus
2 Our findings suggest that elevated levels of superoxide contribute to aging-related impairments in hippocampal LTP and memory, and that these impairments can be alleviated by overexpression of EC-SOD. Superoxides superoxide dismutase 3, extracellular Mus musculus